KMID : 0881720170320040336
|
|
Journal of Food Hygiene and Safety 2017 Volume.32 No. 4 p.336 ~ p.340
|
|
Antimicrobial Activity of Flos syzygii Aromatici Extracts against Mice Infected with Escherichia coli O157:H7
|
|
Lee Soo-Mi
Son Song-Ee Lee Hu-Jang
|
|
Abstract
|
|
|
The present study evaluated the antibacterial effect of Flos syzygii Aromatici methanolic extracts (FSAE). In addition, the effectiveness of FSAE against Escherichia coli O157:H7 infection was studied using ICR female mice. At 24 h after incubation of E. coli O157:H7, FSAE at the concentration of 0.269 (p < 0.05), 0.538 (p < 0.001) and 1.075 mg/mL (p < 0.001) significantly inhibited the growth of E. coli O157:H7 compared to the control group. After single challenge with E. coli
O157:H7, forty female ICR mice were divided into four experimental groups which were orally administered with saline (control), 0.538 (group 1), 1.075 (group 2) and 2.15 mg/mL (group 3) of FSAE, respectively. On the 3rd day, the number of fecal E. coli O157:H7 in group 2 (p < 0.05) and group 3 (p < 0.01) was significantly decreased compared to that in the control group. On the 7th day post-treatment, the number of fecal E. coli O157:H7 in all FSAE-treated groups was significantly decreased compared to that in the control group (group 1, p < 0.05; group 2 and 3, p < 0.001). According to the results of the present study, administration of FSAE to mice can reduce the severity of E. coli O157:H7 infection. Therefore, the current study suggests that FSAE could be a good candidate for the treatment of enteric infections in domestic animals.
|
|
KEYWORD
|
|
Flos syzygii Aromatici, Antibacterial Activity , E. coli O157:H7
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|